2Z8K

Crystal Structure of Escherichia coli gamma-Glutamyltranspeptidase in Complex with Acivicin

Summary for 2Z8K

Entry DOI	10.2210/pdb2z8k/pdb
Related	2Z8I 2Z8J
Descriptor	Gamma-glutamyltranspeptidase, (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, ... (4 entities in total)
Functional Keywords	acivicin formed a covalent bond with thr391, acyltransferase, glutathione biosynthesis, transferase, zymogen
Biological source	Escherichia coli More
Cellular location	Periplasm: P18956 P18956
Total number of polymer chains	4
Total formula weight	119036.56
Authors	Wada, K.,Irie, M.,Fukuyama, K. (deposition date: 2007-09-05, release date: 2008-06-24, Last modification date: 2012-04-04)
Primary citation	Wada, K.,Hiratake, J.,Irie, M.,Okada, T.,Yamada, C.,Kumagai, H.,Suzuki, H.,Fukuyama, K. Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists J.Mol.Biol., 380:361-372, 2008 Cited by PubMed: 18555071 DOI: 10.1016/j.jmb.2008.05.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation