2Z7R
Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine
Summary for 2Z7R
Entry DOI | 10.2210/pdb2z7r/pdb |
Related | 2Z7Q 2Z7S |
Descriptor | Ribosomal protein S6 kinase alpha-1, STAUROSPORINE (3 entities in total) |
Functional Keywords | protein kinase, cancer, kinase inhibitor, atp-binding, magnesium, metal-binding, nucleotide-binding, phosphorylation, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37243.92 |
Authors | Ikuta, M.,Munshi, S.K. (deposition date: 2007-08-28, release date: 2008-05-13, Last modification date: 2023-11-01) |
Primary citation | Ikuta, M.,Kornienko, M.,Byrne, N.,Reid, J.C.,Mizuarai, S.,Kotani, H.,Munshi, S.K. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci., 16:2626-2635, 2007 Cited by PubMed: 17965187DOI: 10.1110/ps.073123707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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