2Z7K

tRNA-Guanine transglycosylase (TGT) in complex with 2-Amino-lin-Benzoguanine

Summary for 2Z7K

• Entry DOI: 10.2210/pdb2z7k/pdb
• Related: 2BBF 2QZR
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 2,6-diamino-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• Functional Keywords: tim barrel, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing
• Biological source: Zymomonas mobilis
• Total number of polymer chains: 1
• Total formula weight: 43299.40

Authors

Ritschel, T.,Heine, A.,Klebe, G. (deposition date: 2007-08-24, release date: 2008-08-26, Last modification date: 2023-11-01)

• Primary citation: Ritschel, T.,Hoertner, S.,Heine, A.,Diederich, F.,Klebe, G.; Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT; Chembiochem, 10:716-727, 2009; PubMed: 19199329; DOI: 10.1002/cbic.200800782

Experimental method

X-RAY DIFFRACTION (1.28 Å)