2Z60

Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A

Summary for 2Z60

Entry DOI	10.2210/pdb2z60/pdb
Related	2QOH
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE (3 entities in total)
Functional Keywords	abl, kinase, mutant, t315i, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphorylation, proto-oncogene, sh2 domain, sh3 domain, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm, cytoskeleton: P00520
Total number of polymer chains	1
Total formula weight	33626.44
Authors	Zhou, T.,Dalgarno, D.,Zhu, X. (deposition date: 2007-07-21, release date: 2007-09-18, Last modification date: 2023-11-01)
Primary citation	Zhou, T.,Parillon, L.,Li, F.,Wang, Y.,Keats, J.,Lamore, S.,Xu, Q.,Shakespeare, W.,Dalgarno, D.,Zhu, X. Crystal Structure of the T315I Mutant of Abl Kinase Chem.Biol.Drug Des., 70:171-181, 2007 Cited by PubMed: 17718712 DOI: 10.1111/j.1747-0285.2007.00556.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation