2Z60

Crystal Structure of the T315I Mutant of Abl kinase bound with PPY-A

2Z60 の概要

• エントリーDOI: 10.2210/pdb2z60/pdb
• 関連するPDBエントリー: 2QOH
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE (3 entities in total)
• 機能のキーワード: abl, kinase, mutant, t315i, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphorylation, proto-oncogene, sh2 domain, sh3 domain, transferase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm, cytoskeleton: P00520
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33626.44

構造登録者

Zhou, T.,Dalgarno, D.,Zhu, X. (登録日: 2007-07-21, 公開日: 2007-09-18, 最終更新日: 2023-11-01)

• 主引用文献: Zhou, T.,Parillon, L.,Li, F.,Wang, Y.,Keats, J.,Lamore, S.,Xu, Q.,Shakespeare, W.,Dalgarno, D.,Zhu, X.; Crystal Structure of the T315I Mutant of Abl Kinase; Chem.Biol.Drug Des., 70:171-181, 2007; PubMed: 17718712; DOI: 10.1111/j.1747-0285.2007.00556.x

実験手法

X-RAY DIFFRACTION (1.95 Å)