2Z3Y

Crystal structure of Lysine-specific demethylase1

2Z3Y の概要

• エントリーDOI: 10.2210/pdb2z3y/pdb
• 関連するPDBエントリー: 2EJR 2Z5U
• 分子名称: Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
• 機能のキーワード: chromatin, histone demethylase, nucleosome, transcription, lsd1, lysine-specific, alternative splicing, chromatin regulator, coiled coil, fad, nucleus, oxidoreductase, phosphorylation, repressor, transcription regulation, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60341
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74571.97

構造登録者

Mimasu, S.,Sengoku, T.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2007-06-08, 公開日: 2008-01-01, 最終更新日: 2024-03-13)

• 主引用文献: Mimasu, S.,Sengoku, T.,Fukuzawa, S.,Umehara, T.,Yokoyama, S.; Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A; Biochem.Biophys.Res.Commun., 366:15-22, 2008; PubMed: 18039463; DOI: 10.1016/j.bbrc.2007.11.066

実験手法

X-RAY DIFFRACTION (2.25 Å)