2YOH

Plasmodium falciparum thymidylate kinase in complex with a urea-alpha- deoxythymidine inhibitor

Summary for 2YOH

Entry DOI	10.2210/pdb2yoh/pdb
Related	2WWF 2WWG 2WWH 2WWI 2YOF 2YOH
Descriptor	THYMIDYLATE KINASE, 1-[[(2R,3S,5S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]-3-(4-nitrophenyl)urea (3 entities in total)
Functional Keywords	transferase, malaria, inhibitor
Biological source	PLASMODIUM FALCIPARUM
Total number of polymer chains	2
Total formula weight	50260.93
Authors	Huaqing, C.,Carrero-Lerida, J.,Silva, A.P.G.,Whittingham, J.L.,Brannigan, J.A.,Ruiz-Perez, L.M.,Read, K.D.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Gilbert, I.H. (deposition date: 2012-10-24, release date: 2013-07-24, Last modification date: 2023-12-20)
Primary citation	Cui, H.,Carrero-Lerida, J.,Silva, A.P.G.,Whittingham, J.L.,Brannigan, J.A.,Ruiz-Perez, L.M.,Read, K.D.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Gilbert, I.H. Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials. J.Med.Chem., 55:10948-, 2012 Cited by PubMed: 23240776 DOI: 10.1021/JM301328H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation