2YOF

Plasmodium falciparum thymidylate kinase in complex with a (thio)urea- beta-deoxythymidine inhibitor

2YOF の概要

• エントリーDOI: 10.2210/pdb2yof/pdb
• 関連するPDBエントリー: 2WWF 2WWG 2WWH 2WWI 2YOG 2YOH
• 分子名称: THYMIDYLATE KINASE, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methyl]thiourea, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, malaria
• 由来する生物種: PLASMODIUM FALCIPARUM
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 76233.57

構造登録者

Huaqing, C.,Carrero-Lerida, J.,Silva, A.P.G.,Whittingham, J.L.,Brannigan, J.A.,Ruiz-Perez, L.M.,Read, K.D.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Gilbert, I.H. (登録日: 2012-10-24, 公開日: 2013-07-24, 最終更新日: 2023-12-20)

• 主引用文献: Cui, H.,Carrero-Lerida, J.,Silva, A.P.G.,Whittingham, J.L.,Brannigan, J.A.,Ruiz-Perez, L.M.,Read, K.D.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Gilbert, I.H.; Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.; J.Med.Chem., 55:10948-, 2012; PubMed: 23240776; DOI: 10.1021/JM301328H

実験手法

X-RAY DIFFRACTION (1.82 Å)