2YKF

Sensor region of a sensor histidine kinase

2YKF の概要

• エントリーDOI: 10.2210/pdb2ykf/pdb
• 関連するPDBエントリー: 2YKH
• 分子名称: PROBABLE SENSOR HISTIDINE KINASE PDTAS, SULFATE ION, BROMIDE ION, ... (4 entities in total)
• 機能のキーワード: transferase, two-component system, gaf domain, pas domain
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33927.36

構造登録者

Preu, J.,Panjikar, S.,Morth, P.,Jaiswal, R.,Karunakar, P.,Tucker, P.A. (登録日: 2011-05-26, 公開日: 2012-06-06, 最終更新日: 2024-05-08)

主引用文献

Preu, J.,Panjikar, S.,Morth, P.,Jaiswal, R.,Karunakar, P.,Tucker, P.A.
The Sensor Region of the Ubiquitous Cytosolic Sensor Kinase, Pdtas, Contains Pas and Gaf Domain Sensing Modules.
J.Struct.Biol., 177:498-, 2012

PubMed Abstract: Two-component systems, a sensor histidine kinase (HK) and a response regulator (RR), are ubiquitous signaling systems that allow prokaryotes to respond to external challenges. HKs normally have sensing modules and highly conserved cytosolic histidine kinase and ATPase domains. The interaction between the activated phosphohistidine and the cognate RR allows an external signal to be passed from the exterior of gram-positive bacteria (GPB) to the cytoplasm. Orthologs of the PdtaS/PdtaR regulatory system, found in most GPB phyla, are unusual in two respects. The HK is not membrane anchored, and the RR acts at the level of transcriptional antitermination. The structure of the complete sensor region of the cytosolic HK, PdtaS, from Mycobacterium tuberculosis consists of closely linked GAF and PAS domains. The structure and sequence analysis suggest that the PdtaS/PdtaR regulatory system is structurally equivalent to the EutW/EutV system regulating ethanolamine catabolism in some phyla but that the effector for the PAS domain is not ethanolamine in the Actinobacteria.

PubMed: 22115998
DOI: 10.1016/J.JSB.2011.11.012

実験手法

X-RAY DIFFRACTION (2 Å)