2YII

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution

2YII の概要

• エントリーDOI: 10.2210/pdb2yii/pdb
• 分子名称: PHENYLALANINE AMMONIA-LYASE, BETA-MERCAPTOETHANOL, FORMIC ACID, ... (5 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: TAXUS WALLICHIANA VAR. CHINENSIS (CHINESE YEW)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 311115.79

構造登録者

Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B. (登録日: 2011-05-13, 公開日: 2011-11-09, 最終更新日: 2023-12-20)

• 主引用文献: Wu, B.,Szymanski, W.,Wybenga, G.G.,Heberling, M.M.,Bartsch, S.,De Wildeman, S.,Poelarends, G.J.,Feringa, B.L.,Dijkstra, B.W.,Janssen, D.B.; Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.; Angew.Chem.Int.Ed.Engl., 51:482-, 2012; PubMed: 22113970; DOI: 10.1002/ANIE.201106372

実験手法

X-RAY DIFFRACTION (2.18 Å)