Structure of L1196M Mutant Anaplastic Lymphoma Kinase

Summary for 2YHV

Related2XB7 2YFX 2XBA 4ANL 4ANQ 4CCB 4CCU 4CD0
DescriptorALK TYROSINE KINASE RECEPTOR (2 entities in total)
Functional Keywordstransferase, receptor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight38614.16
McTigue, M.,Deng, Y.,Liu, W.,Brooun, A. (deposition date: 2011-05-06, release date: 2011-05-18, Last modification date: 2019-05-08)
Primary citation
Huang, Q.,Johnson, T.W.,Bailey, S.,Brooun, A.,Bunker, K.D.,Burke, B.J.,Collins, M.R.,Cook, A.S.,Cui, J.J.,Dack, K.N.,Deal, J.G.,Deng, Y.,Dinh, D.,Engstrom, L.D.,He, M.,Hoffman, J.,Hoffman, R.L.,Johnson, P.S.,Kania, R.S.,Lam, H.,Lam, J.L.,Le, P.T.,Li, Q.,Lingardo, L.,Liu, W.,Lu, M.W.,Mctigue, M.,Palmer, C.L.,Richardson, P.F.,Sach, N.W.,Shen, H.,Smeal, T.,Smith, G.L.,Stewart, A.E.,Timofeevski, S.,Tsaparikos, K.,Wang, H.,Zhu, H.,Zhu, J.,Zou, H.Y.,Edwards, M.P.
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib.
J.Med.Chem., 57:1170-, 2014
PubMed: 24432909 (PDB entries with the same primary citation)
DOI: 10.1021/JM401805H
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers120 1.6% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2yhv
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Molmil generated image of 2yhv
rotated about x axis by 90°
Molmil generated image of 2yhv
rotated about y axis by 90°