2YGC

Structure of vaccinia virus D13 scaffolding protein

2YGC の概要

• エントリーDOI: 10.2210/pdb2ygc/pdb
• 関連するPDBエントリー: 2YGB
• 分子名称: RIFAMPICIN RESISTANCE PROTEIN (2 entities in total)
• 機能のキーワード: viral protein, viral evolution
• 由来する生物種: VACCINIA VIRUS
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 192983.25

構造登録者

Bahar, M.W.,Graham, S.C.,Stuart, D.I.,Grimes, J.M. (登録日: 2011-04-13, 公開日: 2011-07-20, 最終更新日: 2024-11-20)

主引用文献

Bahar, M.W.,Graham, S.C.,Stuart, D.I.,Grimes, J.M.
Insights Into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13.
Structure, 19:1011-, 2011

PubMed Abstract: The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double β barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor.

PubMed: 21742267
DOI: 10.1016/J.STR.2011.03.023

実験手法

X-RAY DIFFRACTION (3.02 Å)