2YEN

Solution structure of the skeletal muscle and neuronal voltage gated sodium channel antagonist mu-conotoxin CnIIIC

2YEN の概要

• エントリーDOI: 10.2210/pdb2yen/pdb
• 分子名称: Mu-conotoxin CnIIIC (1 entity in total)
• 機能のキーワード: toxin, conotoxin, neurotoxin, amidated c-terminus
• 由来する生物種: Conus consors (Singed cone)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2385.78

構造登録者

Favreau, P.,Benoit, E.,Hocking, H.G.,Carlier, L.,D'hoedt, D.,Leipold, E.,Markgraf, R.,Schlumberger, S.,Cordova, M.A.,Gaertner, H.,Paolini-Bertrand, M.,Hartley, O.,Tytgat, J.,Heinemann, S.H.,Bertrand, D.,Boelens, R.,Stocklin, R.,Molgo, J. (登録日: 2011-03-28, 公開日: 2012-02-08, 最終更新日: 2023-06-14)

• 主引用文献: Favreau, P.,Benoit, E.,Hocking, H.G.,Carlier, L.,D'Hoedt, D.,Leipold, E.,Markgraf, R.,Schlumberger, S.,Cordova, M.A.,Gaertner, H.,Paolini-Bertrand, M.,Hartley, O.,Tytgat, J.,Heinemann, S.H.,Bertrand, D.,Boelens, R.,Stocklin, R.,Molgo, J.; A Novel Mu-Conopeptide, Cniiic, Exerts Potent and Preferential Inhibition of Na(V) 1.2/1.4 Channels and Blocks Neuronal Nicotinic Acetylcholine Receptors.; Br.J.Pharmacol., 166:1654-, 2012; PubMed: 22229737; DOI: 10.1111/J.1476-5381.2012.01837.X

実験手法

SOLUTION NMR