2YEL
Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X
Summary for 2YEL
Entry DOI | 10.2210/pdb2yel/pdb |
Related | 2YEK 2YEM |
Descriptor | HUMAN BRD4, 1,2-ETHANEDIOL, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, ... (4 entities in total) |
Functional Keywords | signaling protein, histone, epigenetic reader |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus (By similarity): O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15584.91 |
Authors | Chung, C.W. (deposition date: 2011-03-25, release date: 2011-06-15, Last modification date: 2023-12-20) |
Primary citation | Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E. Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains. J.Med.Chem., 54:3827-, 2011 Cited by PubMed: 21568322DOI: 10.1021/JM200108T PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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