2YAD

BRICHOS domain of Surfactant protein C precursor protein

2YAD の概要

• エントリーDOI: 10.2210/pdb2yad/pdb
• 分子名称: SURFACTANT PROTEIN C BRICHOS DOMAIN (2 entities in total)
• 機能のキーワード: pulmonary surfactant system, interstitial lung disease, amyloid, chaperone, surfactant protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 112253.30

構造登録者

Askarieh, G.,Siponen, M.I.,Willander, H.,Landreh, M.,Westermark, P.,Nordling, K.,Keranen, H.,Hermansson, E.,Hamvas, A.,Nogee, L.M.,Bergman, T.,Saenz, A.,Casals, C.,Aqvist, J.,Jornvall, H.,Presto, J.,Johansson, J.,Arrowsmith, C.H.,Bountra, C.,Collins, R.,Edwards, A.M.,Ekblad, T.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nyman, T.,Nordlund, P.,Persson, C.,Schuler, H.,Thorsell, A.G.,Tresaugues, L.,van den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Berglund, H.,Knight, S.D. (登録日: 2011-02-18, 公開日: 2012-02-15, 最終更新日: 2014-08-13)

• 主引用文献: Willander, H.,Askarieh, G.,Landreh, M.,Westermark, P.,Nordling, K.,Keranen, H.,Hermansson, E.,Hamvas, A.,Nogee, L.M.,Bergman, T.,Saenz, A.,Casals, C.,Aqvist, J.,Jornvall, H.,Berglund, H.,Presto, J.,Knight, S.D.,Johansson, J.; High Resolution Structure of a Bricos Domain and its Implications for Anti-Amyloid Chaperone Activity on Lung Surgactant Protein C.; Proc.Natl.Acad.Sci.USA, 109:2325-, 2012; PubMed: 22308375; DOI: 10.1073/PNAS.1114740109

実験手法

X-RAY DIFFRACTION (2.2 Å)