2Y96

Structure of human dual-specificity phosphatase 27

2Y96 の概要

• エントリーDOI: 10.2210/pdb2y96/pdb
• 分子名称: DUAL SPECIFICITY PHOSPHATASE DUPD1, SULFATE ION (3 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: Q68J44
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51153.20

構造登録者

Lountos, G.T.,Tropea, J.E.,Waugh, D.S. (登録日: 2011-02-11, 公開日: 2011-04-27, 最終更新日: 2023-12-20)

主引用文献

Lountos, G.T.,Tropea, J.E.,Waugh, D.S.
Structure of Human Dual-Specificity Phosphatase at 2.38A Resolution
Acta Crystallogr.,Sect.D, 67:471-, 2011

PubMed Abstract: There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 Å resolution are presented.

PubMed: 21543850
DOI: 10.1107/S090744491100970X

実験手法

X-RAY DIFFRACTION (2.38 Å)