2Y8E
Crystal structure of D. melanogaster Rab6 GTPase bound to GMPPNP
Summary for 2Y8E
| Entry DOI | 10.2210/pdb2y8e/pdb |
| Descriptor | RAB-PROTEIN 6, SULFATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
| Functional Keywords | hydrolase, nucleotide binding, gtp binding |
| Biological source | DROSOPHILA MELANOGASTER (FRUIT FLY) |
| Total number of polymer chains | 2 |
| Total formula weight | 42067.26 |
| Authors | Walden, M.,Edwards, T.A. (deposition date: 2011-02-04, release date: 2011-07-06, Last modification date: 2023-12-20) |
| Primary citation | Walden, M.,Jenkins, H.T.,Edwards, T.A. Structure of the Drosophila Melanogaster Rab6 Gtpase at 1.4 A Resolution Acta Crystallogr.,Sect.F, 67:744-, 2011 Cited by PubMed Abstract: Rab6 is a small GTPase that belongs to the p21 Ras superfamily. It is involved in vesicle trafficking between the Golgi apparatus and endosomes/ER in eukaryotes. The GDP-bound inactive protein undergoes conformational changes when the nucleotide is exchanged to GTP, allowing Rab6 to interact with a variety of different effector proteins. To further understand how these changes affect downstream protein binding, the crystal structure of Rab6 from Drosophila melanogaster has been solved to 1.4 Å resolution, the highest resolution for a Rab6 structure to date. The crystals belonged to space group C2, with unit-cell parameters a=116.5, b=42.71, c=86.86 Å, α=90, β=133.12, γ=90°. The model was refined to an R factor of 14.5% and an Rfree of 17.3%. PubMed: 21795785DOI: 10.1107/S1744309111017453 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.39 Å) |
Structure validation
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