2Y8C

Plasmodium falciparum dUTPase in complex with a trityl ligand

Summary for 2Y8C

• Entry DOI: 10.2210/pdb2y8c/pdb
• Related: 1VYQ
• Descriptor: DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, (2S)-2-[(2,4-dioxopyrimidin-1-yl)methyl]-N-(2-hydroxyethyl)-4-trityloxy-butanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, malaria
• Biological source: PLASMODIUM FALCIPARUM
• Total number of polymer chains: 3
• Total formula weight: 60542.40

Authors

Baragana, B.,McCarthy, O.,Sanchez, P.,Bosch, C.,Kaiser, M.,Brun, R.,Whittingham, J.L.,Roberts, S.,Zhou, X.-X.,Wilson, K.S.,Johansson, N.G.,Gonzalez-Pacanowska, D.,Gilbert, I.H. (deposition date: 2011-02-04, release date: 2012-03-07, Last modification date: 2023-12-20)

• Primary citation: Baragana, B.,Mccarthy, O.,Sanchez, P.,Bosch, C.,Kaiser, M.,Brun, R.,Whittingham, J.L.,Roberts, S.,Zhou, X.-X.,Wilson, K.S.,Johansson, N.G.,Gonzalez-Pacanowska, D.,Gilbert, I.H.; Beta-Branched Acyclic Nucleoside Analogues as Inhibitors of Plasmodium Falciparum Dutpase; Bioorg.Med.Chem., 19:2378-, 2011; PubMed: 21411327; DOI: 10.1016/J.BMC.2011.02.012

Experimental method

X-RAY DIFFRACTION (2.1 Å)