2Y5T

Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide

Summary for 2Y5T

• Entry DOI: 10.2210/pdb2y5t/pdb
• Descriptor: CIIC1 FAB FRAGMENT HEAVY CHAIN, CIIC1 FAB FRAGMENT LIGHT CHAIN, C1, ... (7 entities in total)
• Functional Keywords: immune system, antibody, rheumatoid arthritis, arthritogenic
• Biological source: MUS MUSCULUS (HOUSE MOUSE); More
• Total number of polymer chains: 5
• Total formula weight: 58871.68

Authors

Dobritzsch, D.,Lindh, I.,Schneider, N.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R. (deposition date: 2011-01-17, release date: 2011-12-14, Last modification date: 2023-12-20)

Primary citation

Dobritzsch, D.,Lindh, I.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R.
Crystal Structure of an Arthritogenic Anticollagen Immune Complex.
Arthritis Rheum., 63:3740-, 2011

PubMed Abstract: In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)-specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation.

PubMed: 22127694
DOI: 10.1002/ART.30611

Experimental method

X-RAY DIFFRACTION (2.2 Å)