2Y5T

Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide

2Y5T の概要

• エントリーDOI: 10.2210/pdb2y5t/pdb
• 分子名称: CIIC1 FAB FRAGMENT HEAVY CHAIN, CIIC1 FAB FRAGMENT LIGHT CHAIN, C1, ... (7 entities in total)
• 機能のキーワード: immune system, antibody, rheumatoid arthritis, arthritogenic
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 58871.68

構造登録者

Dobritzsch, D.,Lindh, I.,Schneider, N.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R. (登録日: 2011-01-17, 公開日: 2011-12-14, 最終更新日: 2023-12-20)

主引用文献

Dobritzsch, D.,Lindh, I.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R.
Crystal Structure of an Arthritogenic Anticollagen Immune Complex.
Arthritis Rheum., 63:3740-, 2011

PubMed Abstract: In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)-specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation.

PubMed: 22127694
DOI: 10.1002/ART.30611

実験手法

X-RAY DIFFRACTION (2.2 Å)