2Y2K

PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA5)

2Y2K の概要

• エントリーDOI: 10.2210/pdb2y2k/pdb
• 関連するPDBエントリー: 2UWX 2XD1 2XD5 2Y2G 2Y2H 2Y2I 2Y2J 2Y2L 2Y2M 2Y2N 2Y2O 2Y2P 2Y2Q
• 分子名称: PENICILLIN-BINDING PROTEIN 1B, [(2,6-DIFLUOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: transferase, infection, cell wall, peptidoglycan, inhibitor
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55112.70

構造登録者

Contreras-Martel, C.,Amoroso, A.,Woon, E.,Zervosen, A.,Inglis, S.,Martins, A.,Verlaine, O.,Rydzik, A.,Job, V.,Luxen, A.,Joris, B.,Schofield, C.,Dessen, A. (登録日: 2010-12-15, 公開日: 2011-08-03, 最終更新日: 2023-12-20)

• 主引用文献: Contreras-Martel, C.,Amoroso, A.,Woon, E.C.,Zervosen, A.,Inglis, S.,Martins, A.,Verlaine, O.,Rydzik, A.,Job, V.,Luxen, A.,Joris, B.,Schofield, C.J.,Dessen, A.; Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa).; Acs Chem.Biol, 6:943-, 2011; PubMed: 21732689; DOI: 10.1021/CB2001846

実験手法

X-RAY DIFFRACTION (2.09 Å)