2Y1K

STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (12H SOAK): PHOSPHOSERINE ADDUCT

2Y1K の概要

• エントリーDOI: 10.2210/pdb2y1k/pdb
• 関連するPDBエントリー: 1EHO 1EHQ 1KCJ 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK
• 分子名称: CHOLINESTERASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (9 entities in total)
• 機能のキーワード: hydrolase, inhibition, aging
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62654.43

構造登録者

Carletti, E.,Colletier, J.P.,Nachon, F.,Weik, M. (登録日: 2010-12-08, 公開日: 2011-06-29, 最終更新日: 2023-12-20)

• 主引用文献: Carletti, E.,Schopfer, L.M.,Colletier, J.P.,Froment, M.T.,Nachon, F.,Weik, M.,Lockridge, O.,Masson, P.; Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-Ray Structure Analysis.; Chem.Res.Toxicol., 24:797-, 2011; PubMed: 21438623; DOI: 10.1021/TX100447K

実験手法

X-RAY DIFFRACTION (2.5 Å)