2XXD
HCV-JFH1 NS5B polymerase structure at 1.9 angstrom
Summary for 2XXD
Entry DOI | 10.2210/pdb2xxd/pdb |
Related | 3I5K |
Descriptor | RNA-DIRECTED RNA POLYMERASE, PHOSPHATE ION (3 entities in total) |
Functional Keywords | transferase, hepacivirus, nonstructural proteins, replication, de novo initiation, priming |
Biological source | HEPATITIS C VIRUS (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q99IB8 |
Total number of polymer chains | 1 |
Total formula weight | 62971.82 |
Authors | Caillet-Saguy, C.,Bressanelli, S. (deposition date: 2010-11-10, release date: 2011-01-12, Last modification date: 2024-05-01) |
Primary citation | Schmitt, M.,Scrima, N.,Radujkovic, D.,Caillet-Saguy, C.,Simister, P.C.,Friebe, P.,Wicht, O.,Klein, R.,Bartenschlager, R.,Lohmann, V.,Bressanelli, S. A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes. J.Virol., 85:2565-, 2011 Cited by PubMed: 21209117DOI: 10.1128/JVI.02177-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.881 Å) |
Structure validation
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