2XRA

crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix

2XRA の概要

• エントリーDOI: 10.2210/pdb2xra/pdb
• 関連するPDBエントリー: 1AIK 1DF4 1DF5 1DLB 1G9M 1GC1 1GZL 1K33 1K34 1MZI 1OPN 1OPT 1OPW 1RZJ 2CMR
• 分子名称: TRANSMEMBRANE PROTEIN GP41, HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN, HK20, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN, ... (4 entities in total)
• 機能のキーワード: immune system, antibody, monoclonal cells, neutralization tests
• 由来する生物種: SYNTHETIC CONSTRUCT; 詳細
• 細胞内の位置: Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P04578
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 72961.45

構造登録者

Sabin, C.,Corti, D.,Buzon, V.,Seaman, M.S.,Lutje Hulsik, D.,Hinz, A.,Vanzetta, F.,Agatic, G.,Silacci, C.,Langedijk, J.P.M.,Mainetti, L.,Scarlatti, G.,Sallusto, F.,Weiss, R.,Lanzavecchia, A.,Weissenhorn, W. (登録日: 2010-09-13, 公開日: 2010-12-15, 最終更新日: 2023-12-20)

• 主引用文献: Sabin, C.,Corti, D.,Buzon, V.,Seaman, M.S.,Lutje Hulsik, D.,Hinz, A.,Vanzetta, F.,Agatic, G.,Silacci, C.,Mainetti, L.,Scarlatti, G.,Sallusto, F.,Weiss, R.,Lanzavecchia, A.,Weissenhorn, W.; Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.; PLoS Pathog., 6:e1001195-e1001195, 2010; PubMed: 21124990; DOI: 10.1371/journal.ppat.1001195

実験手法

X-RAY DIFFRACTION (2.3 Å)