2XPC

Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid

2XPC の概要

• エントリーDOI: 10.2210/pdb2xpc/pdb
• 分子名称: UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, (1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: ligase, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase synthesis
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cytoplasm : Q8X9Y9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48338.12

構造登録者

Sosic, I.,Barreteau, H.,Simcic, M.,Sink, R.,Cesar, J.,Golic-Grdadolnik, S.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S. (登録日: 2010-08-26, 公開日: 2011-05-18, 最終更新日: 2023-12-20)

• 主引用文献: Sosi, I.,Barreteau, H.,Sim, M.,Sink, R.,Cesar, J.,Zega, A.,Grdadolnik, S.G.,Contreras-Martel, C.,Dessen, A.,Amoroso, A.,Joris, B.,Blanot, D.,Gobec, S.; Second-Generation Sulfonamide Inhibitors of D- Glutamic Acid-Adding Enzyme: Activity Optimisation with Conformationally Rigid Analogues of D- Glutamic Acid.; Eur.J.Med.Chem, 46:2880-, 2011; PubMed: 21524830; DOI: 10.1016/J.EJMECH.2011.04.011

実験手法

X-RAY DIFFRACTION (1.49 Å)