2XOK

Refined structure of yeast F1c10 ATPase complex to 3 A resolution

2XOK の概要

• エントリーDOI: 10.2210/pdb2xok/pdb
• 関連するPDBエントリー: 2WPD
• 分子名称: ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL, ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL, ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL, ... (8 entities in total)
• 機能のキーワード: hydrolase, atp-binding, f(o), f(1), atp synthase, mitochondria, inner membrane, transmembrane
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST); 詳細
• タンパク質・核酸の鎖数: 19
• 化学式量合計: 478949.31

構造登録者

Stock, D.,W Leslie, A.G.,Walker, J.E. (登録日: 2010-08-18, 公開日: 2010-09-22, 最終更新日: 2023-12-20)

主引用文献

Stock, D.,Leslie, A.G.,Walker, J.E.
Molecular architecture of the rotary motor in ATP synthase.
Science, 286:1700-1705, 1999

PubMed Abstract: Adenosine triphosphate (ATP) synthase contains a rotary motor involved in biological energy conversion. Its membrane-embedded F0 sector has a rotation generator fueled by the proton-motive force, which provides the energy required for the synthesis of ATP by the F1 domain. An electron density map obtained from crystals of a subcomplex of yeast mitochondrial ATP synthase shows a ring of 10 c subunits. Each c subunit forms an alpha-helical hairpin. The interhelical loops of six to seven of the c subunits are in close contact with the gamma and delta subunits of the central stalk. The extensive contact between the c ring and the stalk suggests that they may rotate as an ensemble during catalysis.

PubMed: 10576729
DOI: 10.1126/science.286.5445.1700

実験手法

X-RAY DIFFRACTION (3.01 Å)