2XMZ

Structure of MenH from S. aureus

2XMZ の概要

• エントリーDOI: 10.2210/pdb2xmz/pdb
• 分子名称: HYDROLASE, ALPHA/BETA HYDROLASE FOLD FAMILY (2 entities in total)
• 機能のキーワード: menaquinone biosynthesis, lyase
• 由来する生物種: STAPHYLOCOCCUS AUREUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31019.18

構造登録者

Dawson, A.,Fyfe, P.K.,Gillet, F.,Hunter, W.N. (登録日: 2010-07-30, 公開日: 2011-05-25, 最終更新日: 2023-12-20)

主引用文献

Dawson, A.,Fyfe, P.K.,Gillet, F.,Hunter, W.N.
Exploiting the High-Resolution Crystal Structure of Staphylococcus Aureus Menh to Gain Insight Into Enzyme Activity.
Bmc Struct.Biol., 11:19-, 2011

PubMed Abstract: MenH (2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase) is a key enzyme in the biosynthesis of menaquinone, catalyzing an unusual 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate.

PubMed: 21513522
DOI: 10.1186/1472-6807-11-19

実験手法

X-RAY DIFFRACTION (1.94 Å)