2XE8
The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and AMP-PNP
Summary for 2XE8
Entry DOI | 10.2210/pdb2xe8/pdb |
Related | 2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 |
Descriptor | PHOSPHOGLYCERATE KINASE 1, 3-PHOSPHOGLYCERIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | transition state analogue, hereditary hemolytic anemia, phosphoprotein, kinase, glycolysis, transferase, phosphoryl transfer, nucleotide-binding, domain motions |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P00558 |
Total number of polymer chains | 1 |
Total formula weight | 45363.89 |
Authors | Cliff, M.J.,Baxter, N.J.,Blackburn, G.M.,Merli, A.,Vas, M.,Waltho, J.P.,Bowler, M.W. (deposition date: 2010-05-11, release date: 2011-01-19, Last modification date: 2023-12-20) |
Primary citation | Zerrad, L.,Merli, A.,Schroder, G.F.,Varga, A.,Graczer, E.,Pernot, P.,Round, A.,Vas, M.,Bowler, M.W. A Spring Loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase. J.Biol.Chem., 286:14040-, 2011 Cited by PubMed: 21349853DOI: 10.1074/JBC.M110.206813 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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