2XDA

STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH INHIBITOR COMPOUND (4R,6R,7S)-2-(2-Cyclopropyl)ethyl-4,6,7- trihydroxy-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid

Summary for 2XDA

Entry DOI	10.2210/pdb2xda/pdb
Related	1J2Y 2C4V 2C4W 2C57 2WKS 2XB9 2XD9
Descriptor	3-DEHYDROQUINATE DEHYDRATASE, (4R,6R,7S)-2-(2-CYCLOPROPYLETHYL)-4,6,7-TRIHYDROXY-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-4-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	aromatic amino acid biosynthesis, lyase
Biological source	HELICOBACTER PYLORI
Total number of polymer chains	1
Total formula weight	18797.60
Authors	Paz, S.,Tizon, L.,Otero, J.M.,Llamas-Saiz, A.L.,Fox, G.C.,van Raaij, M.J.,Lamb, H.,Hawkins, A.R.,Castedo, L.,Gonzalez-Bello, C. (deposition date: 2010-04-30, release date: 2010-11-24, Last modification date: 2023-12-20)
Primary citation	Paz, S.,Tizon, L.,Otero, J.M.,Llamas-Saiz, A.L.,Fox, G.C.,van Raaij, M.J.,Lamb, H.,Hawkins, A.R.,Lapthorn, A.J.,Castedo, L.,Gonzalez-Bello, C. Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6:266-272, 2011 Cited by PubMed: 21275050 DOI: 10.1002/cmdc.201000343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation