2XB7

Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684

2XB7 の概要

分子名称ALK TYROSINE KINASE RECEPTOR, 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE (3 entities in total)
機能のキーワードatp-binding, receptor, transferase
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Membrane; Single-pass type I membrane protein Q9UM73
ポリマー鎖数1
分子量合計35948.82
構造登録者
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Fogliatto, G.,Bertrand, J.A. (登録日: 2010-04-08, 公開日: 2010-07-28, 最終更新日: 2011-07-13)
主引用文献
Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Avanzi, N.,Borgia, A.L.,Nesi, M.,Bandiera, T.,Fogliatto, G.,Bertrand, J.A.
Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
Biochemistry, 49:6813-, 2010
PubMed: 20695522 (主引用文献が同じPDBエントリー)
DOI: 10.1021/BI1005514
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.5 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197130.4%2.8%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード