2X7I

Crystal structure of mevalonate kinase from methicillin-resistant Staphylococcus aureus MRSA252

2X7I の概要

• エントリーDOI: 10.2210/pdb2x7i/pdb
• 分子名称: MEVALONATE KINASE, CITRIC ACID, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: STAPHYLOCOCCUS AUREUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33343.55

構造登録者

Oke, M.,Yan, X.,Carter, L.G.,Johnson, K.A.,Liu, H.,Mcmahon, S.A.,White, M.F.,Naismith, J.H. (登録日: 2010-02-27, 公開日: 2010-07-21, 最終更新日: 2024-05-08)

主引用文献

Oke, M.,Carter, L.G.,Johnson, K.A.,Liu, H.,Mcmahon, S.A.,Yan, X.,Kerou, M.,Weikart, N.D.,Kadi, N.,Sheikh, M.A.,Schmelz, S.,Dorward, M.,Zawadzki, M.,Cozens, C.,Falconer, H.,Powers, H.,Overton, I.M.,Van Niekerk, C.A.J.,Peng, X.,Patel, P.,Garrett, R.A.,Prangishvili, D.,Botting, C.H.,Coote, P.J.,Dryden, D.T.F.,Barton, G.J.,Schwarz-Linek, U.,Challis, G.L.,Taylor, G.L.,White, M.F.,Naismith, J.H.
The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11:167-, 2010

PubMed Abstract: The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology.

PubMed: 20419351
DOI: 10.1007/S10969-010-9090-Y

実験手法

X-RAY DIFFRACTION (2.2 Å)