2X7F
Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1 inhibitor
Summary for 2X7F
Entry DOI | 10.2210/pdb2x7f/pdb |
Descriptor | TRAF2 AND NCK-INTERACTING PROTEIN KINASE, 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, SODIUM ION, ... (4 entities in total) |
Functional Keywords | serine/threonine-protein kinase, phosphoprotein, kinase, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: Q9UKE5 |
Total number of polymer chains | 5 |
Total formula weight | 187959.49 |
Authors | Vollmar, M.,Alfano, I.,Shrestha, B.,Bray, J.,Muniz, J.R.C.,Roos, A.,Filippakopoulos, P.,Burgess-Brown, N.,Ugochukwu, E.,Gileadi, O.,Phillips, C.,Mahajan, P.,Pike, A.C.W.,Fedorov, O.,Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S. (deposition date: 2010-02-26, release date: 2010-07-14, Last modification date: 2023-12-20) |
Primary citation | Vollmar, M.,Alfano, I.,Shrestha, B.,Bray, J.,Muniz, J.R.C.,Roos, A.,Filippakopoulos, P.,Burgess-Brown, N.,Ugochukwu, E.,Gileadi, O.,Phillips, C.,Mahajan, P.,Pike, A.C.W.,Fedorov, O.,Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S. Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor To be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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