2X77

Crystal Structure of Leishmania major ADP ribosylation factor-like 1.

2X77 の概要

• エントリーDOI: 10.2210/pdb2x77/pdb
• 分子名称: ADP-RIBOSYLATION FACTOR, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: gtp-binding protein, small gtpase, nucleotide-binding
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42950.93

構造登録者

Fleming, J.R.,Dawson, A.,Hunter, W.N. (登録日: 2010-02-24, 公開日: 2010-03-02, 最終更新日: 2024-11-06)

主引用文献

Fleming, J.R.,Dawson, A.,Hunter, W.N.
Crystal Structure of Leishmania Major Adp Ribosylation Factor-Like 1 and a Classification of Related Gtpase Family Members in This Kinetoplastid.
Mol.Biochem.Parasitol., 174:141-, 2010

PubMed Abstract: ADP-ribosylation factor-like (ARL) proteins are small GTPases that undergo conformational changes upon nucleotide binding, and which regulate the affinity of ARLs for binding other proteins, lipids or membranes. There is a paucity of structural data on this family of proteins in the Kinetoplastida, despite studies implicating them in key events related to vesicular transport and regulation of microtubule-dependent processes. The crystal structure of Leishmania major ARL1 in complex with GDP has been determined to 2.1 Å resolution and reveals a high degree of structural conservation with human ADP-ribosylation factor 1 (ARF1). Putative L. major and Trypanosoma brucei ARF/ARL family members have been classified based on structural considerations, amino acid sequence conservation combined with functional data on Kinetoplastid and human orthologues. This classification may guide future studies designed to elucidate the function of specific family members.

PubMed: 20801163
DOI: 10.1016/J.MOLBIOPARA.2010.08.002

実験手法

X-RAY DIFFRACTION (2.1 Å)