2X24

bovine ACC2 CT domain in complex with inhibitor

2X24 の概要

• エントリーDOI: 10.2210/pdb2x24/pdb
• 分子名称: ACETYL-COA CARBOXYLASE, TERT-BUTYL [(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE (3 entities in total)
• 機能のキーワード: fatty acid biosynthesis, ligase, lipid synthesis
• 由来する生物種: BOS TAURUS (CATTLE)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 179767.31

構造登録者

Oster, L.,Folmer, R.,Blaho, S.,Wiberg, F.,Hallberg, K. (登録日: 2010-01-11, 公開日: 2011-01-26, 最終更新日: 2024-05-08)

• 主引用文献: Bengtsson, C.,Blaho, S.,Saitton, D.B.,Brickmann, K.,Broddefalk, J.,Davidsson, O.,Drmota, T.,Folmer, R.,Hallberg, K.,Hallen, S.,Hovland, R.,Isin, E.,Johannesson, P.,Kull, B.,Larsson, L.,Lofgren, L.,Nilsson, K.E.,Noeske, T.,Oakes, N.,Plowright, A.T.,Schnecke, V.,Stahlberg, P.,Sorme, P.,Wan, H.,Wellner, E.,Oster, L.; Design of Small Molecule Inhibitors of Acetyl-Coa Carboxylase 1 and 2 Showing Reduction of Hepatic Malonyl-Coa Levels in Vivo in Obese Zucker Rats.; Bioorg.Med.Chem., 19:3039-, 2011; PubMed: 21515056; DOI: 10.1016/J.BMC.2011.04.014

実験手法

X-RAY DIFFRACTION (2.4 Å)