2WZO

The structure of the FYR domain

2WZO の概要

• エントリーDOI: 10.2210/pdb2wzo/pdb
• 分子名称: TRANSFORMING GROWTH FACTOR BETA REGULATOR 1, GLYCEROL (3 entities in total)
• 機能のキーワード: nucleus, cell cycle, tumor suppressor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q3YBR2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16140.42

構造登録者

Garcia-Alai, M.M.,Allen, M.D.,Joerger, A.C.,Bycroft, M. (登録日: 2009-12-01, 公開日: 2010-05-05, 最終更新日: 2024-05-08)

主引用文献

Garcia-Alai, M.M.,Allen, M.D.,Joerger, A.C.,Bycroft, M.
The Structure of the Fyr Domain of Transforming Growth Factor Beta Regulator 1 (Tbrg1)(Pna)
Protein Sci., 19:1432-, 2010

PubMed Abstract: Many chromatin-associated proteins contain two sequence motifs rich in phenylalanine/tyrosine residues of unknown function. These so-called FYRN and FYRC motifs are also found in transforming growth factor beta regulator 1 (TBRG1)/nuclear interactor of ARF and MDM2 (NIAM), a growth inhibitory protein that also plays a role in maintaining chromosomal stability. We have solved the structure of a fragment of TBRG1, which encompasses both of these motifs. The FYRN and FYRC regions each form part of a single folded module (the FYR domain), which adopts a novel alpha + beta fold. Proteins such as the histone H3K4 methyltransferases trithorax and mixed lineage leukemia (MLL), in which the FYRN and FYRC regions are separated by hundreds of amino acids, are expected to contain FYR domains with a large insertion between two of the strands of the beta-sheet.

PubMed: 20506279
DOI: 10.1002/PRO.404

実験手法

X-RAY DIFFRACTION (1.6 Å)