2WYN

Structure of family 37 trehalase from Escherichia coli in complex with a casuarine-6-O-a-D-glucoside analogue

2WYN の概要

• エントリーDOI: 10.2210/pdb2wyn/pdb
• 関連するPDBエントリー: 2JF4 2JG0 2JJB
• 分子名称: PERIPLASMIC TREHALASE, (1R,2R,3R,6R,7R,7AR)-3,7-BIS(HYDROXYMETHYL)HEXAHYDRO-1H-PYRROLIZINE-1,2,6-TRIOL, alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase, glycosidase, glycoside hydrolase
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 246817.78

構造登録者

Gloster, T.M.,Roberts, S.M.,Davies, G.J.,Cardona, F.,Goti, A.,Parmeggiani, C.,Parenti, P.,Fusi, P.,Forcella, M.,Cipolla, L. (登録日: 2009-11-17, 公開日: 2010-09-29, 最終更新日: 2024-10-16)

主引用文献

Cardona, F.,Goti, A.,Parmeggiani, C.,Parenti, P.,Forcella, M.,Fusi, P.,Cipolla, L.,Roberts, S.M.,Davies, G.J.,Gloster, T.M.
Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.
Chem.Commun.(Camb.), 46:2629-2631, 2010

PubMed Abstract: Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

PubMed: 20461849
DOI: 10.1039/b926600c

実験手法

X-RAY DIFFRACTION (2.1 Å)