2WXK
The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.
Summary for 2WXK
Entry DOI | 10.2210/pdb2wxk/pdb |
Related | 2WXE 2WXF 2WXG 2WXH 2WXI 2WXJ 2WXL 2WXM 2WXN 2WXO 2WXP 2WXQ 2WXR |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 3-(2-amino-1,3-benzothiazol-6-yl)-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2 entities in total) |
Functional Keywords | transferase, phosphoprotein, isoform-specific inhibitors, cancer |
Biological source | MUS MUSCULUS (HOUSE MOUSE) |
Total number of polymer chains | 1 |
Total formula weight | 108346.29 |
Authors | Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. (deposition date: 2009-11-09, release date: 2010-01-12, Last modification date: 2023-12-20) |
Primary citation | Berndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L. The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol., 6:117-, 2010 Cited by PubMed: 20081827DOI: 10.1038/NCHEMBIO.293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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