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2WXK

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666.

Summary for 2WXK
Entry DOI10.2210/pdb2wxk/pdb
Related2WXE 2WXF 2WXG 2WXH 2WXI 2WXJ 2WXL 2WXM 2WXN 2WXO 2WXP 2WXQ 2WXR
DescriptorPHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 3-(2-amino-1,3-benzothiazol-6-yl)-1-{[2-(4-methylpiperazin-1-yl)quinolin-3-yl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2 entities in total)
Functional Keywordstransferase, phosphoprotein, isoform-specific inhibitors, cancer
Biological sourceMUS MUSCULUS (HOUSE MOUSE)
Total number of polymer chains1
Total formula weight108346.29
Authors
Primary citationBerndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L.
The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6:117-, 2010
Cited by
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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