2WQP

Crystal structure of sialic acid synthase NeuB-inhibitor complex

Summary for 2WQP

• Entry DOI: 10.2210/pdb2wqp/pdb
• Descriptor: POLYSIALIC ACID CAPSULE BIOSYNTHESIS PROTEIN SIAC, 5-(ACETYLAMINO)-3,5-DIDEOXY-2-O-PHOSPHONO-D-ERYTHRO-L-MANNO-NONONIC ACID, MANGANESE (II) ION, ... (7 entities in total)
• Functional Keywords: neub, inhibitor, tim barrel, sialic acid synthase, transferase
• Biological source: NEISSERIA MENINGITIDIS
• Total number of polymer chains: 1
• Total formula weight: 39768.33

Authors

Liu, F.,Lee, H.J.,Strynadka, N.C.J.,Tanner, M.E. (deposition date: 2009-08-25, release date: 2009-09-15, Last modification date: 2011-10-12)

• Primary citation: Liu, F.,Lee, H.J.,Strynadka, N.C.J.,Tanner, M.E.; The Inhibition of Neisseria Meningitidis Sialic Acid Synthase by a Tetrahedral Intermediate Analog.; Biochemistry, 48:9194-, 2009; PubMed: 19719325; DOI: 10.1021/BI9012758

Experimental method

X-RAY DIFFRACTION (1.75 Å)