2WQO

STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950

Summary for 2WQO

Entry DOI	10.2210/pdb2wqo/pdb
Related	2JAV 2W5A 2W5B 2W5H 2WQM 2WQN
Descriptor	SERINE/THREONINE-PROTEIN KINASE NEK2, 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	kinase, nucleus, meiosis, mitosis, cytoplasm, alternative splicing, serine/threonine-protein kinase, metal-binding, phosphoprotein, nucleotide-binding, magnesium, cell cycle, atp-binding, transferase, coiled coil, polymorphism, cell division
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	33149.23
Authors	Mas-Droux, C.,Bayliss, R. (deposition date: 2009-08-24, release date: 2009-12-08, Last modification date: 2011-07-13)
Primary citation	Richards, M.W.,O'Regan, L.,Mas-Droux, C.,Blot, J.M.,Cheung, J.,Hoelder, S.,Fry, A.M.,Bayliss, R. An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9. Mol.Cell, 36:560-, 2009 Cited by PubMed: 19941817 DOI: 10.1016/J.MOLCEL.2009.09.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.167 Å)

Structure validation