2WPU

Chaperoned ruthenium metallodrugs that recognize telomeric DNA

2WPU の概要

• エントリーDOI: 10.2210/pdb2wpu/pdb
• 関連するPDBエントリー: 1DF8 1HQQ 1HXL 1HXZ 1HY2 1I9H 1KFF 1KL3 1KL4 1KL5 1LCV 1LCW 1LCZ 1LUQ 1MEP 1MK5 1MM9 1MOY 1N43 1N4J 1N7Y 1N9M 1N9Y 1NBX 1NC9 1NDJ 1NQM 1PTS 1RST 1RSU 1RXH 1RXJ 1RXK 1SLD 1SLE 1SLF 1SLG 1SRE 1SRF 1SRG 1SRH 1SRI 1SRJ 1STP 1STR 1STS 1SWA 1SWB 1SWC 1SWD 1SWE 1SWF 1SWG 1SWH 1SWJ 1SWK 1SWL 1SWN 1SWO 1SWP 1SWQ 1SWR 1SWS 1SWT 1SWU 1VWA 1VWB 1VWC 1VWD 1VWE 1VWF 1VWG 1VWH 1VWI 1VWJ 1VWK 1VWL 1VWM 1VWN 1VWO 1VWP 1VWQ 1VWR 2BC3 2F01 2IZA 2IZB 2IZC 2IZD 2IZE 2IZF 2IZG 2IZH 2IZI 2IZJ 2IZK 2IZL 2RTA 2RTB 2RTC 2RTD 2RTE 2RTF 2RTG 2RTH 2RTI 2RTJ 2RTK 2RTL 2RTM 2RTN 2RTO 2RTP 2RTQ 2RTR
• 分子名称: STREPTAVIDIN, (3AS,4S,6AR)-4-(5-((3R,4R)-3,4-DIAMINOPYRROLIDIN-1-YL)-5-OXOPENTYL)TETRAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-2(3H)-ONE-P-CYMENE-CHLORO-RUTHENIUM(III), SULFATE ION, ... (5 entities in total)
• 機能のキーワード: biotin binding protein
• 由来する生物種: STREPTOMYCES AVIDINII
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17356.36

構造登録者

Heinisch, T.,Schirmer, T.,Zimbron, J.M.,Sardo, A.,Wohlschlager, T.,Gradinaru, J.,Creus, M.,Ward, T.R. (登録日: 2009-08-10, 公開日: 2010-10-13, 最終更新日: 2023-12-20)

• 主引用文献: Zimbron, J.M.,Sardo, A.,Heinisch, T.,Wohlschlager, T.,Gradinaru, J.,Massa, C.,Schirmer, T.,Creus, M.,Ward, T.R.; Chemo-Genetic Optimization of DNA Recognition by Metallodrugs Using a Presenter-Protein Strategy.; Chemistry, 16:12883-, 2010; PubMed: 20878805; DOI: 10.1002/CHEM.201001573

実験手法

X-RAY DIFFRACTION (1.92 Å)