2WPO
HCMV protease inhibitor complex
Summary for 2WPO
Entry DOI | 10.2210/pdb2wpo/pdb |
Related PRD ID | PRD_000229 |
Descriptor | HUMAN CYTOMEGALOVIRUS PROTEASE, (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide (2 entities in total) |
Functional Keywords | viral protease, hydrolase-hydrolase inhibitor complex, coat protein, serine protease, hydrolase/hydrolase inhibitor |
Biological source | Human herpesvirus 5 (Human cytomegalovirus) |
Cellular location | Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753 |
Total number of polymer chains | 4 |
Total formula weight | 115553.16 |
Authors | Tong, L.,Qian, C.,Massariol, M.-J.,Deziel, R.,Yoakim, C.,Lagace, L. (deposition date: 1998-08-04, release date: 1999-08-04, Last modification date: 2023-08-09) |
Primary citation | Tong, L.,Qian, C.,Massariol, M.J.,Deziel, R.,Yoakim, C.,Lagace, L. Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease. Nat.Struct.Biol., 5:819-826, 1998 Cited by PubMed: 9731777DOI: 10.1038/1860 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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