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2WPO

HCMV protease inhibitor complex

Summary for 2WPO
Entry DOI10.2210/pdb2wpo/pdb
Related PRD IDPRD_000229
DescriptorHUMAN CYTOMEGALOVIRUS PROTEASE, (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide (2 entities in total)
Functional Keywordsviral protease, hydrolase-hydrolase inhibitor complex, coat protein, serine protease, hydrolase/hydrolase inhibitor
Biological sourceHuman herpesvirus 5 (Human cytomegalovirus)
Cellular locationProtease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
Total number of polymer chains4
Total formula weight115553.16
Authors
Tong, L.,Qian, C.,Massariol, M.-J.,Deziel, R.,Yoakim, C.,Lagace, L. (deposition date: 1998-08-04, release date: 1999-08-04, Last modification date: 2023-08-09)
Primary citationTong, L.,Qian, C.,Massariol, M.J.,Deziel, R.,Yoakim, C.,Lagace, L.
Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.
Nat.Struct.Biol., 5:819-826, 1998
Cited by
PubMed: 9731777
DOI: 10.1038/1860
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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