2WPO

HCMV protease inhibitor complex

2WPO の概要

• エントリーDOI: 10.2210/pdb2wpo/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000229
• 分子名称: HUMAN CYTOMEGALOVIRUS PROTEASE, (2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide (2 entities in total)
• 機能のキーワード: viral protease, hydrolase-hydrolase inhibitor complex, coat protein, serine protease, hydrolase/hydrolase inhibitor
• 由来する生物種: Human herpesvirus 5 (Human cytomegalovirus)
• 細胞内の位置: Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 115553.16

構造登録者

Tong, L.,Qian, C.,Massariol, M.-J.,Deziel, R.,Yoakim, C.,Lagace, L. (登録日: 1998-08-04, 公開日: 1999-08-04, 最終更新日: 2023-08-09)

• 主引用文献: Tong, L.,Qian, C.,Massariol, M.J.,Deziel, R.,Yoakim, C.,Lagace, L.; Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease.; Nat.Struct.Biol., 5:819-826, 1998; PubMed: 9731777; DOI: 10.1038/1860

実験手法

X-RAY DIFFRACTION (2.7 Å)