2WL7

Crystal structure of the PSD93 PDZ1 domain

2WL7 の概要

• エントリーDOI: 10.2210/pdb2wl7/pdb
• 分子名称: DISKS LARGE HOMOLOG 2, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: delta2 receptor interacting protein, transferase, dlg2, maguk, psd93, pdz domain, chapsyn-110
• 由来する生物種: MUS MUSCULUS (MOUSE)
• 細胞内の位置: Membrane; Lipid-anchor (By similarity): Q91XM9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11277.97

構造登録者

Fiorentini, M.,Kallehauge, A.,Kristensen, O.,Kastrup, J.S.,Gajhede, M. (登録日: 2009-06-22, 公開日: 2010-01-19, 最終更新日: 2023-12-13)

主引用文献

Fiorentini, M.,Nielsen, A.K.,Kristensen, O.,Kastrup, J.S.,Gajhede, M.
Structure of the First Pdz Domain of Human Psd-93.
Acta Crystallogr.,Sect.F, 65:1254-, 2009

PubMed Abstract: The crystal structure of the PDZ1 domain of human PSD-93 has been determined to 2.0 A resolution. The PDZ1 domain forms a crystallographic trimer that is also predicted to be stable in solution. The main contributions to the stabilization of the trimer seem to arise from interactions involving the PDZ1-PDZ2 linker region at the extreme C-terminus of PDZ1, implying that the oligomerization that is observed is not of biological significance in full-length PSD-93. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition. However, the cleft is significantly narrower in PSD-95. This could be part of the basis of peptide selectivity between PSD-93 PDZ1 and PSD-95 PDZ1.

PubMed: 20054121
DOI: 10.1107/S1744309109043267

実験手法

X-RAY DIFFRACTION (2.028 Å)