2WKS
Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.
Summary for 2WKS
Entry DOI | 10.2210/pdb2wks/pdb |
Related | 1J2Y 2C4V 2C4W 2C57 |
Descriptor | 3-DEHYDROQUINATE DEHYDRATASE, (1R,4S,5R)-1,4,5-trihydroxy-3-[(5-methyl-1-benzothiophen-2-yl)methoxy]cyclohex-2-ene-1-carboxylic acid (3 entities in total) |
Functional Keywords | aromatic amino acid biosynthesis, lyase, shikimic acid pathway, 3-dehydroquinate dehydratase |
Biological source | HELICOBACTER PYLORI |
Total number of polymer chains | 6 |
Total formula weight | 113097.79 |
Authors | Otero, J.M.,Guardado-Calvo, P.,Llamas-Saiz, A.L.,Prazeres, V.F.V.,Tizon, L.,Castedo, L.,Lamb, H.,Hawkins, A.R.,Gonzalez-Bello, C.,van Raaij, M.J. (deposition date: 2009-06-17, release date: 2009-11-24, Last modification date: 2023-12-13) |
Primary citation | Prazeres, V.F.,Tizon, L.,Otero, J.M.,Guardado-Calvo, P.,Llamas-Saiz, A.L.,van Raaij, M.J.,Castedo, L.,Lamb, H.,Hawkins, A.R.,Gonzalez-Bello, C. Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues. J. Med. Chem., 53:191-200, 2010 Cited by PubMed: 19911771DOI: 10.1021/jm9010466 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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