2WKL

Velaglucerase alfa

Summary for 2WKL

• Entry DOI: 10.2210/pdb2wkl/pdb
• Related: 1OGS 1Y7V 2F61 2J25 2V3D 2V3E 2V3F
• Descriptor: GLUCOSYLCERAMIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: alternative initiation, sphingolipid metabolism, membrane, lysosome, hydrolase, ichthyosis, n-nonyl-deoxynojirimycin, n-nonyl-deoxynojirimycin alternative initiation, disulfide bond, pharmaceutical, gaucher disease, glycosidase, polymorphism, glycoprotein, alternative splicing, acid-beta-glucosidase, lipid metabolism, disease mutation, velaglucerase alfa
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 114117.58

Authors

Brumshtein, B.,Salinas, P.,Peterson, B.,Chan, V.,Silman, I.,Sussman, J.L.,Savickas, P.J.,Robinson, G.S.,Futerman, A.H. (deposition date: 2009-06-15, release date: 2009-09-22, Last modification date: 2023-12-13)

• Primary citation: Brumshtein, B.,Salinas, P.,Peterson, B.,Chan, V.,Silman, I.,Sussman, J.L.,Savickas, P.J.,Robinson, G.S.,Futerman, A.H.; Characterization of Gene-Activated Human Acid-Beta-Glucosidase: Crystal Structure, Glycan Composition and Internalization Into Macrophages.; Glycobiology, 20:24-, 2010; PubMed: 19741058; DOI: 10.1093/GLYCOB/CWP138

Experimental method

X-RAY DIFFRACTION (2.7 Å)