2WJW

Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution

2WJW の概要

• エントリーDOI: 10.2210/pdb2wjw/pdb
• 関連するPDBエントリー: 2WJX
• 分子名称: GLUTAMATE RECEPTOR 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: transport protein, postsynaptic cell membrane, glur2, synapse, membrane, receptor, palmitate, synaptic plasticity, alternative splicing, ion transport, cell junction, cell membrane, transmembrane, phosphoprotein, glutamate receptors, polymorphism, glycoprotein, ionic channel, transport, ion channel, rna editing, lipoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44187.10

構造登録者

Clayton, A.,Siebold, C.,Gilbert, R.J.C.,Sutton, G.C.,Harlos, K.,McIlhinney, R.A.J.,Jones, E.Y.,Aricescu, A.R. (登録日: 2009-06-01, 公開日: 2009-08-18, 最終更新日: 2024-10-16)

主引用文献

Clayton, A.,Siebold, C.,Gilbert, R.J.C.,Sutton, G.C.,Harlos, K.,Mcilhinney, R.A.J.,Jones, E.Y.,Aricescu, A.R.
Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors.
J.Mol.Biol., 392:1125-, 2009

PubMed Abstract: Ionotropic glutamate receptors are functionally diverse but have a common architecture, including the 400-residue amino-terminal domain (ATD). We report a 1.8-A resolution crystal structure of human GluR2-ATD. This dimeric structure provides a mechanism for how the ATDs can drive receptor assembly and subtype-restricted composition. Lattice contacts in a 4.1-A resolution crystal form reveal a tetrameric (dimer-dimer) arrangement consistent with previous cellular and cryo-electron microscopic data for full-length AMPA receptors.

PubMed: 19651138
DOI: 10.1016/J.JMB.2009.07.082

実験手法

X-RAY DIFFRACTION (1.8 Å)