2WG4

Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium

Summary for 2WG4

Entry DOI	10.2210/pdb2wg4/pdb
Related	1VHH 2WFQ 2WFR 2WFT 2WFX 2WG3
Descriptor	SONIC HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ... (4 entities in total)
Functional Keywords	autocatalytic cleavage, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein, signaling protein, lipoprotein, development, glycoprotein, cell membrane, disulfide bond, egf-like domain, hedgehog signaling
Biological source	MUS MUSCULUS (MOUSE) More
Cellular location	Sonic hedgehog protein N-product: Cell membrane ; Lipid-anchor : Q62226 Cell membrane ; Peripheral membrane protein . Isoform 2: Cytoplasm : Q96QV1
Total number of polymer chains	2
Total formula weight	68736.90
Authors	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-15, release date: 2009-06-30, Last modification date: 2023-12-13)
Primary citation	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611 DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation