2WFX

Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium

Summary for 2WFX

• Entry DOI: 10.2210/pdb2wfx/pdb
• Related: 1VHH 2WFT 2WG3 2WG4 2WGQ 2WGR
• Descriptor: SONIC HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ... (5 entities in total)
• Functional Keywords: signaling protein, autocatalytic cleavage, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein, lipoprotein, development, glycoprotein, cell membrane, disulfide bond, egf-like domain, hedgehog signaling
• Biological source: MUS MUSCULUS (MOUSE); More
• Cellular location: Sonic hedgehog protein C-product: Secreted, extracellular space. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor: Q62226; Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1
• Total number of polymer chains: 2
• Total formula weight: 68592.85

Authors

Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-15, release date: 2009-06-30, Last modification date: 2023-12-13)

• Primary citation: Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C.; Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip; Nat.Struct.Mol.Biol., 16:698-, 2009; PubMed: 19561611; DOI: 10.1038/NSMB.1607

Experimental method

X-RAY DIFFRACTION (3.2 Å)