2WFX
Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium
Summary for 2WFX
Entry DOI | 10.2210/pdb2wfx/pdb |
Related | 1VHH 2WFT 2WG3 2WG4 2WGQ 2WGR |
Descriptor | SONIC HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ... (5 entities in total) |
Functional Keywords | signaling protein, autocatalytic cleavage, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein, lipoprotein, development, glycoprotein, cell membrane, disulfide bond, egf-like domain, hedgehog signaling |
Biological source | MUS MUSCULUS (MOUSE) More |
Cellular location | Sonic hedgehog protein C-product: Secreted, extracellular space. Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor: Q62226 Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1 |
Total number of polymer chains | 2 |
Total formula weight | 68592.85 |
Authors | Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-15, release date: 2009-06-30, Last modification date: 2023-12-13) |
Primary citation | Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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