2WFT

Crystal structure of the human HIP ectodomain

Summary for 2WFT

Entry DOI	10.2210/pdb2wft/pdb
Related	2WFQ 2WFR 2WFX 2WG3 2WG4
Descriptor	HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	membrane, secreted, cytoplasm, development, disulfide bond, egf-like domain, hedgehog signalling, signal transduction, alternative splicing, polymorphism, glycoprotein, cell membrane, signaling protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Peripheral membrane protein (By similarity). Isoform 2: Cytoplasm (Probable): Q96QV1
Total number of polymer chains	2
Total formula weight	102433.41
Authors	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-15, release date: 2009-06-30, Last modification date: 2011-07-13)
Primary citation	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611 DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation